What we check
Polygenic scores, marker calls, medication-response genetics, HLA context where callable, evidence links, actionability, redundancy, and safety boundaries.
Method
How Spoke decides what belongs in a report.
We screen widely, then show only signals with enough evidence, relevance, and safety context to be useful.
Most possible DNA signals do not become report findings. Spoke ranks traits and variants by usefulness, evidence strength, ancestry portability, redundancy, and safety before anything is shown.
The goal is not to show every possible association. The goal is to produce a focused report that helps you decide what is worth checking, discussing, or safely ignoring for now.
18K+
genetic traits screened and prioritised
119M+
variant records standardised
66K+
evidence records connected to traits
What sits outside the report
Current lab testing, symptom assessment, medication review, formal screening pathways, and whole-genome clinical variant interpretation.
How to use it
Treat the report as a prioritisation map. Measured results, symptoms, family history, medication context, and clinician judgement decide what changes now.
Prioritisation
We choose what is worth showing.
Traits and variants are ranked by actionability, inherited signal, value beyond ordinary biomarkers, validation, ancestry portability, redundancy, and safety.
Genetic modelling
We use research-aware mapping, not simple SNP lookup.
Raw DNA is harmonised, quality checked, and mapped with LD-aware polygenic scoring approaches where the file and evidence support it.
Mechanisms
We go from scores to practical routes.
We look for links to relevant biomarkers, symptoms, family-history questions, clinician conversations, and everyday habits.
Evidence layer
We connect findings to checks, actions, and boundaries.
Results are connected to biomarkers, practical actions, clinician discussion points, and safety limits before they become report guidance.
Genome processing flow
A raw file is checked, modelled, connected to evidence, and translated into report priorities.
01
DNA file
Your raw DNA data is processed securely.
02
Quality checks
Coverage checks and confidence tiers are applied.
03
Genetic scoring
Polygenic scores are calibrated to reference data where suitable.
04
Evidence mapping
Findings are linked to checks, actions, and safety context.
05
Prioritised report
The report turns evidence into priorities and boundaries.
Spoke reports are not diagnoses and do not replace clinical genetic testing, medication review, or formal screening. They help organise what may be worth checking next.
Check file compatibility