Spoke DNA Reports by Spoke Bio
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Spoke DNA Reports by Spoke Bio

Genome
Action Plan

A practical guide to the parts of your DNA that may be worth checking, tracking, or simply keeping in the background.

Inside: your bottom line, a small starter plan, a GP-ready summary, and a full transparency library if you want the details. The point is not to make your DNA feel dramatic; it is to help you know what to do with it.

Personally
prioritised

Focused on insights most relevant to your health and life stage.

Clinically
grounded

Curated with robust evidence and genomic science.

Actionable
next steps

Clear practical guidance you can discuss with your clinician.

Clear
boundaries

Transparent about what we report and what we intentionally exclude.

Designed to help you focus on what matters most, not to diagnose.
Private  |  Confidential  |  For your health Not for reproduction or distribution.
Insights for today. Clarity for the future.
Your report in plain English

Contents.

Use this as a map. Start with the required steps, then open optional detail only when it helps.

No urgent DNA-only action

Nothing here means you need to panic, change treatment, or request urgent care from DNA alone.

Check against real life

Use symptoms, family history, previous results, and routine markers such as liver, glucose, lipids, iron/B12, thyroid, or vitamin D where relevant.

Try for 14 days

Start with three small experiments: prioritised actions that could be most impactful for you, with the option to swap in others.

Save for care conversations

Keep the GP brief and medication notes for clinician or pharmacist discussions. They are context, not instructions.

Input quality checked PRS + selected markers Not diagnostic sequencing Generated 2026-06-09 · UK 24 use now 15 check if relevant 206 background
Optional
How to interpret technical detail. Use this to help you decode percentile, PRS, marker, PGx, or decision-making label terms.
4 keys
Interpretation guide

Four things to know when you open the detail.

This report is a prioritisation map. It helps sort your DNA into a more useful order: tendencies you may already recognise, simple actions that may suit your biology, and a smaller set of things worth checking with blood tests, measurements, symptoms, or clinician input.

A higher percentile means your inherited signal is higher than most people in the comparison population. It is not a diagnosis. The most useful interpretation comes from combining your DNA with real-life evidence: how you feel, what runs in your family, what your blood tests show, and what changes when you try sensible everyday levers.

Reading a percentile A bar like this means your inherited signal sits higher than about 87% of the comparison group. It is a comparison between people - not a diagnosis or a personal probability. The faint centre line marks the 50th percentile (an average result).
Use now - a few signals connected to the starter plan. Check if relevant - useful only when symptoms, labs, history, or medicines line up. No extra action - context you can leave in the background. Meds - pharmacogenomic notes, relevant at prescribing moments only.
PRSPolygenic scores are relative signals. They help prioritise checks; they are not absolute-risk predictions.
VariantSingle-marker rows are context; confirmation matters when clinical action would change.
PGxMedication-response findings matter at prescribing moments, not as general health findings.
Decision labelsThe first label tells you whether to use it now, check only if context agrees, or leave it in the background.
GlossaryPlain definitions for the terms used in this report
Transparency library245176 polygenic scores and 69 marker/PGx context rows.
Decision model24 / 15 / 206Use-now, check-if-relevant, and background counts.
Versionv5Generated 2026-06-09 for a UK-localised report.
From the health-area signal map

Overall, there is good news here, with a few useful checks to consider.

You have 12 health areas with lower signal, 27 appear typical or steady, with 16 areas worth checking against real life.

Step 2 of 6
Review top prioritised follow-ups at a glance. Start with the top 5 useful findings, then review the matching habits, checks, and care notes that follow from them.

This is the handoff from summary to action: use the small steps that fit real life, and ignore the rest for now.

5 findings
Prioritised follow-ups Selected from the top 5 useful findings above, then bounded by symptoms, measured results, family history, and routine care context.
i

Personalisation inputs. This ordering uses your DNA signal pattern, age/sex context, report region, actionability, and safety boundaries. Symptoms, labs, family history, medications, and goals still decide what matters now.

Open doctor notes and blood-test follow-ups
Step 3 of 6
Your starter 14-day plan. Try the tiny version first, then review what felt easy enough to keep.

These selected levers are the experiment for the next 14 days. Use the swap drawer only if you need a better fit, not as extra homework.

3 experiments
How to use it

Start tiny. Do not add homework.

Open a card only when you want the detail. Each habit has one cue, one tiny version, and a clear stop-or-escalate boundary.

14days to try
7day review point
Selected experiments

These are prefilled from your report. Keep the light plan unless a card genuinely does not fit your day.

Starter mix: 1 daily anchor, 1 food or routine experiment, 1 signal-matched challenge.

Chosen for safety fit, evidence strength, relevance to your report signals, repeatability, and low friction.

Daily anchor 3-5x/week 1-2x/week Only if relevant

Post-meal walking prescription

Daily · habit fit 96 After the largest meal of the day, I will take the short walk or do the backup stairs/calf-raise option, then mark it done.
Why this ranked for youIt ranked because glucose-risk context, HbA1c, and Triglycerides sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
AnchorAfter the largest meal of the day, I will take the short walk or do the backup stairs/calf-raise option, then mark it done.
Tiny versionWalk for five minutes after the largest meal, or do one minute of stairs or calf raises. That counts.
Make it easyChoose the meal and route before the day starts, so the cue is the plate being cleared.
TrackY/N: moved after the largest meal. Optional: energy, sleepiness, reflux, or glucose when measured.
EscalateChest pain, fainting, unusual breathlessness, injury symptoms, or glucose-range concerns belong in the clinician lane.

Protein anchor with meals

3-5x/week · habit fit 91 After I build the meal I most often under-build, I will add a clear protein source, then mark it done.
Why this ranked for youIt ranked because glucose-risk context, HbA1c, and Osteoporosis sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
AnchorAfter I build the meal I most often under-build, I will add a clear protein source, then mark it done.
Tiny versionAdd one palm-sized or obvious protein item to one meal. That counts.
Make it easyPre-decide two protein defaults that require almost no cooking.
TrackY/N: protein anchor included. Optional: hunger, snacking, recovery, or digestion.
EscalateKidney disease, medical diets, or worsening digestion should use tailored dietary advice.

Resistance training rhythm

1-2x/week · habit fit 85 After I put on training shoes or finish the warm-up, I will do the first set, then mark it done.
Why this ranked for youIt ranked because glucose-risk context, HbA1c, and Osteoporosis sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
AnchorAfter I put on training shoes or finish the warm-up, I will do the first set, then mark it done.
Tiny versionOne set of one movement, or three controlled squats. That counts.
Make it easyPick two repeatable days and leave the band, weights, or plan visible.
TrackY/N: first set done. Optional: soreness, pain, sleep, or load used.
EscalateSharp pain, neurologic symptoms, chest pain, fainting, or major injury symptoms override the plan.
Day 7 reviewKeep the anchors that felt least dramatic, remove one friction point, and let the tiny version save the streak when life gets busy.
Day 14 decisionKeep, scale, switch, or stop. If symptoms, labs, family history, medication, or a diagnosis makes an experiment higher-stakes, take the GP or pharmacist route.

This is enough for the next two weeks. The swap-in drawer is optional.

More levers you can swap in18 total options grouped by effort. Customise only if you want to. 18 shown
Evidence
Health area
Effort

Simple

6 shown

Low friction and easy to trial.

Movement

Post-meal walking prescription

Daily · habit fit 96
Simple lever · Strong mechanistic
Why this ranked for youIt ranked because glucose-risk context, HbA1c, and Triglycerides sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysAfter the largest carbohydrate meal, walk 10 to 15 minutes within an hour. If time is tight, do stairs, calf raises, or a short walk with the buggy/dog.
AnchorAfter the largest meal of the day, I will take the short walk or do the backup stairs/calf-raise option, then mark it done.
Tiny versionWalk for five minutes after the largest meal, or do one minute of stairs or calf raises. That counts.
Make it easyChoose the meal and route before the day starts, so the cue is the plate being cleared.
TrackY/N: moved after the largest meal. Optional: energy, sleepiness, reflux, or glucose when measured.
Adjust / stopProgress gradually; pain, chest symptoms, fainting, unusual breathlessness, or poor recovery means scale back and seek care if needed; safety exclusions override.
EscalateChest pain, fainting, unusual breathlessness, injury symptoms, or glucose-range concerns belong in the clinician lane.
Type 2 diabetes >90%HbA1c >90%Triglycerides 77thHemoglobin 78th
Alcohol, liver & medicationsEnergy & nutrients
Fibre and plants

Protein or vegetables first at mixed meals

Daily · habit fit 95
Simple lever · Strong broad
Why this may fitIt ranked because glucose-risk context, Irritable bowel syndrome, and HbA1c sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysAt mixed meals, eat vegetables or protein first, then starch or dessert; start with breakfast or dinner.
AnchorAfter I sit down for my first mixed meal of the day, I will eat protein or vegetables first, then mark it done.
Tiny versionDo the smallest visible version. That counts.
Make it easyPut the food cue where that meal is built, or write the rule on the meal plan.
TrackY/N: did the behaviour. Optional: one outcome that matters to you.
Adjust / stopUse measured glucose and clinical context to decide whether to continue or intensify; scale back if energy, fuelling, or symptoms worsen; safety exclusions override.
EscalateIf symptoms, abnormal labs, pregnancy, medication, or a diagnosis make this higher-stakes, use the GP or pharmacist route.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this simple option in only if it fits your current goal or symptoms.
Type 2 diabetes >90%Irritable bowel syndrome >90%HbA1c >90%Triglycerides 77th
Energy & nutrientsGut, food & immune
Caffeine

Sugary-drink zero default

Daily · habit fit 95
Simple lever · Strong mechanistic
Why this may fitIt ranked because glucose-risk context, HbA1c, and Triglycerides sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysMake water, unsweetened tea/coffee, or zero-sugar options the default for everyday drinks; keep fruit juice and sugary drinks occasional.
AnchorAfter I reach for an everyday drink, I will choose the zero-sugar default first, then mark it done.
Tiny versionSwap one usual sugary drink for water, unsweetened tea, coffee, or a zero-sugar option. That counts.
Make it easyMake the default drink visible and move sugary drinks out of the automatic reach spot.
TrackY/N: used the default drink. Optional: cravings or afternoon energy.
Adjust / stopIf cravings rebound, replace rather than remove: sparkling water, tea, or planned occasional sweet drinks.
EscalateIf thirst, weight change, or glucose symptoms are unusual, check measured glucose rather than treating this as the answer.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this simple option in only if it fits your current goal or symptoms.
Type 2 diabetes >90%HbA1c >90%Triglycerides 77thHemoglobin 78th
Alcohol, liver & medicationsEnergy & nutrients
Movement

Break up long sitting

Daily · habit fit 95
Simple lever · Strong broad
Why this may fitIt ranked because glucose-risk context, HbA1c, and Malaise and fatigue sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysEvery 30-60 minutes, stand and move for 2-5 minutes; pair it with calls, kettle breaks or calendar nudges.
AnchorAfter a timer, call, or kettle-break cue, I will stand and move briefly, then mark it done.
Tiny versionDo the smallest visible version. That counts.
Make it easyUse the calendar, watch, kettle, or call ending as the movement cue.
TrackY/N: did the behaviour. Optional: one outcome that matters to you.
Adjust / stopProgress gradually; pain, chest symptoms, fainting, unusual breathlessness, or poor recovery means scale back and seek care if needed; safety exclusions override.
EscalateIf symptoms, abnormal labs, pregnancy, medication, or a diagnosis make this higher-stakes, use the GP or pharmacist route.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this simple option in only if it fits your current goal or symptoms.
Type 2 diabetes >90%HbA1c >90%Malaise and fatigue 85thTriglycerides 77th
Heart & metabolicSleep & fitness
Everyday lever

Oat/barley beta-glucan breakfast

Daily · habit fit 95
Simple lever · Strong broad
Why this may fitIt ranked because glucose-risk context, LDL cholesterol, and HbA1c sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysUse oats, barley, oat bran or a high-beta-glucan cereal as a default breakfast or lunch base on 5+ days/week; pair with nuts or fruit rather than sugary toppings.
AnchorAfter I start breakfast or my first meal, I will do the tiny version, then mark it done.
Tiny versionDo the smallest visible version. That counts.
Make it easyPut the food cue where that meal is built, or write the rule on the meal plan.
TrackY/N: did the behaviour. Optional: one outcome that matters to you.
Adjust / stopUse measured markers to decide whether to continue, intensify, or move the question into GP or clinician review; safety exclusions override the experiment.
EscalateIf symptoms, abnormal labs, pregnancy, medication, or a diagnosis make this higher-stakes, use the GP or pharmacist route.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this simple option in only if it fits your current goal or symptoms.
Type 2 diabetes >90%LDL cholesterol >90%HbA1c >90%Apolipoprotein B 78th
Energy & nutrientsHeart & metabolic
Everyday lever

Nuts as snack replacement

Daily · habit fit 94
Simple lever · Strong broad
Why this may fitIt ranked because glucose-risk context, LDL cholesterol, and HbA1c sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysReplace a processed snack with a small handful of unsalted nuts most days, adjusting total calories if weight is drifting up.
AnchorAfter I reach for the usual snack, I will choose the planned tiny swap first, then mark it done.
Tiny versionDo the smallest visible version. That counts.
Make it easyWrite the swap on the shopping list, or put the replacement where the usual choice happens.
TrackY/N: did the behaviour. Optional: one outcome that matters to you.
Adjust / stopReduce intensity if digestion, restriction, or energy worsens; use measured results to decide whether it is worth continuing; safety exclusions override the.
EscalateIf symptoms, abnormal labs, pregnancy, medication, or a diagnosis make this higher-stakes, use the GP or pharmacist route.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this simple option in only if it fits your current goal or symptoms.
Type 2 diabetes >90%LDL cholesterol >90%HbA1c >90%Apolipoprotein B 78th
Energy & nutrientsHeart & metabolic

Intermediate

6 shown

Moderate setup with meaningful compounding.

Fibre and plants

Saturated-fat swap list

3-5x/week · habit fit 91
Intermediate lever · Strong mechanistic
Why this may fitIt ranked because LDL cholesterol, Statin-associated muscle symptom., and Total cholesterol sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern.
Try for 14 daysChoose the swaps in advance: butter to olive/rapeseed oil, cream to Greek yoghurt, fatty processed meat to fish/poultry/legumes, cheese-heavy lunches to.
AnchorAfter I write the shopping list or choose lunch, I will make one planned saturated-fat swap, then mark it done.
Tiny versionDo the smallest visible version. That counts.
Make it easyWrite the swap on the shopping list, or put the replacement where the usual choice happens.
TrackY/N: did the behaviour. Optional: one outcome that matters to you.
Adjust / stopUse measured markers to decide whether to continue, intensify, or move the question into GP or clinician review; safety exclusions override the experiment.
EscalateIf symptoms, abnormal labs, pregnancy, medication, or a diagnosis make this higher-stakes, use the GP or pharmacist route.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this intermediate option in only if it fits your current goal.
LDL cholesterol >90%Statin-associated muscle symptom. markerTotal cholesterol 13thHDL cholesterol 25th
Alcohol, liver & medicationsGut, food & immune
Strength

Protein anchor with meals

3-5x/week · habit fit 91
Intermediate lever · Strong
Why this ranked for youIt ranked because glucose-risk context, HbA1c, and Osteoporosis sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysPut a clear protein source into the meals you most often under-build.
AnchorAfter I build the meal I most often under-build, I will add a clear protein source, then mark it done.
Tiny versionAdd one palm-sized or obvious protein item to one meal. That counts.
Make it easyPre-decide two protein defaults that require almost no cooking.
TrackY/N: protein anchor included. Optional: hunger, snacking, recovery, or digestion.
Adjust / stopChange protein source or portion if digestion worsens; use kidney-disease or medical dietary advice
EscalateKidney disease, medical diets, or worsening digestion should use tailored dietary advice.
Type 2 diabetes >90%HbA1c >90%Osteoporosis 90thMalaise and fatigue 85th
Energy & nutrientsHeart & metabolic
Movement

Progressive resistance training

3-5x/week · habit fit 90
Intermediate lever · Strong mechanistic
Why this may fitIt ranked because Osteoporosis, Malaise and fatigue, and Sex hormone-binding globulin sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier.
Try for 14 days2-4 days/week, major movement patterns, 6-12 exercises, controlled progression in reps/load, and at least one rest day between hard sessions for the same muscle.
AnchorAfter I put on training shoes or finish the warm-up, I will do the tiny movement version, then mark it done.
Tiny versionDo the smallest visible version. That counts.
Make it easyLeave the shoes, band, weights, or plan where the session starts.
TrackY/N: did the behaviour. Optional: one outcome that matters to you.
Adjust / stopProgress gradually; pain, chest symptoms, fainting, unusual breathlessness, or poor recovery means scale back and seek care if needed; safety exclusions override.
EscalateIf symptoms, abnormal labs, pregnancy, medication, or a diagnosis make this higher-stakes, use the GP or pharmacist route.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this intermediate option in only if it fits your current goal.
Osteoporosis 90thMalaise and fatigue 85thSex hormone-binding globulin 82ndAppendicular lean mass 81st
Energy & nutrientsHeart & metabolic
Movement

Zone 2 aerobic base

1-2x/week · habit fit 90
Intermediate lever · Strong
Why this may fitIt ranked because glucose-risk context, HbA1c, and Anxiety disorder sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysBuild 20-30 minutes of brisk walking, cycling, swimming, or similar effort 3-5 days/week; you should still be able to talk.
AnchorAfter I put on shoes for a planned movement slot, I will move at talk-test pace, then mark it done.
Tiny versionFive minutes at an easy brisk pace. That counts.
Make it easyChoose the route or kit before the day starts, so the decision is already made.
TrackY/N: talk-test session. Optional: resting heart rate, sleep, soreness, or energy.
Adjust / stopAdd duration before intensity; stop and seek care for chest pain, fainting, or unusual breathlessness.
EscalateChest pain, fainting, unusual breathlessness, or new injury symptoms override the plan.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this intermediate option in only if it fits your current goal.
Type 2 diabetes >90%HbA1c >90%Anxiety disorder >90%Migraine 85th
Gut, food & immuneHeart & metabolic
Fibre and plants

Triglyceride rescue plate

3-5x/week · habit fit 89
Intermediate lever · Strong broad
Why this may fitIt ranked because glucose-risk context, HbA1c, and Triglycerides sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysFor high triglycerides, build meals around protein, non-starchy vegetables, legumes or whole grains in controlled portions, and unsaturated fats; target refined.
AnchorAfter I plan lunch or dinner, I will build the tiny rescue-plate version first, then mark it done.
Tiny versionDo the smallest visible version. That counts.
Make it easyChoose one default plate before the meal: protein, plants, controlled starch, and unsaturated fat.
TrackY/N: did the behaviour. Optional: one outcome that matters to you.
Adjust / stopUse measured markers to decide whether to continue, intensify, or move the question into GP or clinician review; safety exclusions override the experiment.
EscalateIf symptoms, abnormal labs, pregnancy, medication, or a diagnosis make this higher-stakes, use the GP or pharmacist route.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this intermediate option in only if it fits your current goal.
Type 2 diabetes >90%HbA1c >90%Triglycerides 77thAlcohol consumption tendency 24th
Alcohol, liver & medicationsHeart & metabolic
Fibre and plants

Daily fibre anchor

3-5x/week · habit fit 89
Intermediate lever · Strong
Why this may fitIt ranked because glucose-risk context, LDL cholesterol, and Irritable bowel syndrome sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier.
Try for 14 daysAdd one daily fibre anchor: beans, oats, berries, vegetables, chia/flax, or whole grains; increase gradually with water.
AnchorAfter I make breakfast or my most reliable meal, I will add one fibre anchor, then mark it done.
Tiny versionAdd one spoon of oats, beans, berries, seeds, or vegetables. That counts.
Make it easyPut the chosen fibre food at eye level or next to the meal it belongs
TrackY/N: fibre anchor added. Optional: stool pattern, bloating, or hunger.
Adjust / stopReduce dose and build slower if bloating or pain increases; use symptom-led care for red flags.
EscalateRed flags such as bleeding, weight loss, severe pain, or persistent bowel change need clinical review.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this intermediate option in only if it fits your current goal.
Type 2 diabetes >90%LDL cholesterol >90%Irritable bowel syndrome >90%HbA1c >90%
Alcohol, liver & medicationsEnergy & nutrients

Challenge

6 shown

Higher effort, larger potential payoff.

Strength

Resistance training rhythm

1-2x/week · habit fit 85
Challenge lever · Strong broad
Why this ranked for youIt ranked because glucose-risk context, HbA1c, and Osteoporosis sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysSet a repeatable rhythm: 2-3 sessions/week, basic movement patterns, gradual load, and recovery days.
AnchorAfter I put on training shoes or finish the warm-up, I will do the first set, then mark it done.
Tiny versionOne set of one movement, or three controlled squats. That counts.
Make it easyPick two repeatable days and leave the band, weights, or plan visible.
TrackY/N: first set done. Optional: soreness, pain, sleep, or load used.
Adjust / stopProgress slowly; sharp pain, neurologic symptoms, chest pain, or major injury symptoms override the plan.
EscalateSharp pain, neurologic symptoms, chest pain, fainting, or major injury symptoms override the plan.
Type 2 diabetes >90%HbA1c >90%Osteoporosis 90thMalaise and fatigue 85th
Energy & nutrientsHeart & metabolic
Fibre and plants

LDL-lowering food portfolio

3-5x/week · habit fit 82
Challenge lever · Strong broad
Why this may fitIt ranked because LDL cholesterol, Apolipoprotein B, and Total cholesterol sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysLayer oats or barley, nuts, legumes/soy or other plant protein, and less saturated fat from routine defaults.
AnchorAfter I choose breakfast or lunch, I will add one LDL-portfolio food, then mark it done.
Tiny versionAdd oats, barley, nuts, beans, soy or another plant protein once. That counts.
Make it easyPut one portfolio food where the meal decision happens.
TrackY/N: portfolio food used. Optional: digestion, saturated-fat swaps, ApoB or LDL-C when measured.
Adjust / stopUse measured ApoB/LDL-C to decide whether food changes are enough or GP prevention discussion is needed.
EscalateMeasured ApoB/LDL-C decides whether food changes are enough or a GP prevention discussion is needed.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this challenge option in only if it fits your current goal or symptoms.
LDL cholesterol >90%Apolipoprotein B 78thTotal cholesterol 13thIschemic stroke 32nd
Heart & metabolic
Everyday lever

Diabetes-prevention activity target

3-5x/week · habit fit 82
Challenge lever · Strong
Why this may fitIt ranked because glucose-risk context, HbA1c, and Triglycerides sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysIf HbA1c or fasting glucose is borderline, discuss a Diabetes Prevention Program-style target: gradual weight loss if appropriate plus 150 minutes/week of activity.
AnchorAfter I check my weekly calendar, I will place the next activity slot, then mark it done.
Tiny versionBook or do ten minutes of activity. That counts.
Make it easyPut the activity slots on the calendar before the week fills up.
TrackY/N: activity slot done. Optional: weekly minutes, waist/weight if useful, HbA1c, or fasting glucose.
Adjust / stopUse measured glucose and clinical context to decide intensity; avoid weight-loss targets if inappropriate or harmful.
EscalateUse measured glucose and clinical context before weight-loss targets; avoid targets that are inappropriate or harmful.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this challenge option in only if it fits your current goal or symptoms.
Type 2 diabetes >90%HbA1c >90%Triglycerides 77thTCF7L2 glucose marker marker
Heart & metabolicSleep & fitness
Movement

Exercise snacks

1-2x/week · habit fit 78
Challenge lever · Moderate
Why this may fitIt ranked because glucose-risk context, HbA1c, and Malaise and fatigue sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysTry 3 x 20-second stair climbs or hard efforts separated through the day, 3 days/week, after warming up if needed.
AnchorAfter a safe stairs, wall-sit, or brisk-walk cue, I will do one tiny movement snack, then mark it done.
Tiny versionDo the smallest visible version. That counts.
Make it easyPick the safe movement option and the place it happens before the cue arrives.
TrackY/N: did the behaviour. Optional: one outcome that matters to you.
Adjust / stopProgress gradually; pain, chest symptoms, fainting, unusual breathlessness, or poor recovery means scale back and seek care if needed; safety exclusions override.
EscalateIf symptoms, abnormal labs, pregnancy, medication, or a diagnosis make this higher-stakes, use the GP or pharmacist route.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this challenge option in only if it fits your current goal or symptoms.
Type 2 diabetes >90%HbA1c >90%Malaise and fatigue 85thPhysical activity <10%
Heart & metabolicSleep & fitness
Sleep timing

CBT-I first-line pathway

1-2x/week · habit fit 78
Challenge lever · Strong mechanistic
Why this may fitIt ranked because Anxiety disorder, Malaise and fatigue, and Depression sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysOffer digital CBT-I, trained therapist CBT-I, or structured self-help before sedative escalation: sleep education, stimulus control, sleep compression/restriction.
AnchorAfter I brush my teeth at night, I will start the tiny sleep cue, then mark it done.
Tiny versionDo the smallest visible version. That counts.
Make it easyPut the sleep cue beside the toothbrush, charger, book, or bedside light.
TrackY/N: did the behaviour. Optional: one outcome that matters to you.
Adjust / stopShift gradually; scale back if sleep, anxiety, daytime function, or breathing symptoms worsen; safety exclusions override the experiment.
EscalateIf symptoms, abnormal labs, pregnancy, medication, or a diagnosis make this higher-stakes, use the GP or pharmacist route.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this challenge option in only if it fits your current goal or symptoms.
Anxiety disorder >90%Malaise and fatigue 85thDepression 78thInsomnia <10%
Sleep & fitness
Sleep timing

Alcohol reduction block

Daily · habit fit 78
Challenge lever · Strong safety-gated
Why this may fitIt ranked because Anxiety disorder, alcohol-use tendency, and Migraine sit in your signal mix, and this is an ordinary, low-risk experiment that can make that pattern easier to read.
Try for 14 daysRun a defined reduction block: fewer units, more alcohol-free days, or earlier cutoff for 2-4 weeks.
AnchorAfter dinner or the first usual drink cue, I will choose the reduction rule first, then mark it done.
Tiny versionMake the first drink alcohol-free, or move the cut-off earlier. That counts.
Make it easyPut the alcohol-free option in the usual drink spot before the cue arrives.
TrackY/N: reduction rule used. Optional: sleep, reflux, mood, HR/HRV, or units.
Adjust / stopIf cutting down is difficult or withdrawal symptoms appear, use clinical support rather than willpower-only experimentation.
EscalateWithdrawal symptoms or difficulty cutting down deserve clinical support, not willpower-only experimentation.
Not in starter planNot in the starter plan because the first two weeks stay deliberately small; swap this challenge option in only if it fits your current goal or symptoms.
Anxiety disorder >90%Alcohol dependence >90%Migraine 85thTriglycerides 77th
Alcohol, liver & medicationsHeart & metabolic

How to use this. Genetics prioritises experiments; measured results, symptoms, preferences, and clinician judgement decide what matters now.

Optional
Findings worth using now. Before you explore the full trait landscape, this shows the most useful findings connected to your prioritised areas.
6 areas
Cardiometabolic & VascularHeart, lipids, blood sugar, blood pressure, body composition
6 priority2 conditional27 bg
LDL cholesterol Use now

High inherited LDL-C signal. This makes an ApoB-inclusive lipid panel more worth doing.

Linked to: Measure the lipid particle layer
LowHigh
>90%Percentile
Type 2 diabetes Use now

Glucose-control cluster. Your DNA points toward higher type 2 diabetes susceptibility.

Linked to: Confirm the glucose and HbA1c pattern
LowHigh
>90%Percentile
HbA1c Use now

Higher inherited HbA1c signal. The useful question is whether this shows up in measured HbA1c and fasting glucose.

Linked to: Confirm the glucose and HbA1c pattern
LowHigh
>90%Percentile
Dilated cardiomyopathy Use now

Heart-muscle context. A common-variant signal is not a cardiomyopathy diagnosis, but family history and symptoms can make it

LowHigh
85Percentile
Apolipoprotein B Use now

Higher inherited ApoB signal. ApoB helps show the number of atherogenic particles better than a headline cholesterol value alone.

Linked to: Measure the lipid particle layer
LowHigh
78Percentile
Immune, Inflammation & AllergyAutoimmunity, allergy, inflammation, respiratory immune context
4 priority0 conditional12 bg
Allergic rhinitis Use now

Allergy-route context. The signal matters most if symptoms line up with seasonal, dust, animal, mould, food, asthma, eczema, or family-history patterns.

LowHigh
>90%Percentile
Systemic lupus erythematosus Use now

Autoimmune-context signal. This is not a lupus diagnosis; it is only useful if symptoms, family history, or abnormal routine tests point toward autoimmune review.

LowHigh
>90%Percentile
Ankylosing spondylitis Use now

Immune and inflammatory back-pain context. This signal belongs with immune/joint history, not rare-sensory findings.

LowHigh
89Percentile
Asthma Use now

Airway-symptom route finder. The DNA signal is useful when wheeze, cough, exercise limitation, nocturnal symptoms, allergy, reflux, infections, or family history line up.

Linked to: Let symptoms choose the gut-testing route
LowHigh
75Percentile
Gut, Digestion & Food ResponseIBD, bowel pattern, reflux, food response, microbiome context
3 priority0 conditional23 bg
Irritable bowel syndrome Use now

Higher inherited signal for Irritable bowel syndrome; measured phenotype decides whether that signal is showing up now.

Linked to: Let symptoms choose the gut-testing route
LowHigh
>90%Percentile
Ulcerative colitis Use now

Higher inherited signal for Ulcerative colitis; measured phenotype decides whether that signal is showing up now.

Linked to: Let symptoms choose the gut-testing route
LowHigh
>90%Percentile
Inflammatory bowel disease Use now

Higher inherited signal for Inflammatory bowel disease; measured phenotype decides whether that signal is showing up now.

Linked to: Let symptoms choose the gut-testing route
LowHigh
85Percentile
Brain, Mood & StressMood, stress, attention, migraine, sensitive psychiatric context
3 priority0 conditional7 bg
Anxiety disorder Use now

Stress-sensitivity context. This signal is useful only when current symptoms, sleep, caffeine, alcohol, workload, or family history point the same way.

LowHigh
>90%Percentile
Attention-deficit/hyperactivity disorder Use now

Attention and executive-function context. The DNA signal is not an ADHD diagnosis; it is a prompt to look at current function and modifiable contributors.

LowHigh
79Percentile
Depression Use now

Mood-vulnerability context. The useful question is current mood, sleep, activity, social withdrawal, medicines, alcohol, and life stress - not DNA in isolation.

LowHigh
78Percentile
Skin, Eyes, Oral & Sensory HealthSkin, eyes, hearing, oral health and sensory context
2 priority0 conditional8 bg
Primary open-angle glaucoma Use now

Eye-exam prompt. A higher glaucoma PRS is most useful as a reason to keep optometry or ophthalmology checks

LowHigh
>90%Percentile
Acne Use now

Skin-and-hormone context. A higher acne signal is not urgent; it helps explain tendency only alongside current severity, scarring risk, medications, hormones, and skin-care tolerance.

LowHigh
76Percentile
Fitness, Movement, Bone & PainFitness, migraine, bone, joints, muscle, pain and recovery
2 priority0 conditional14 bg
Osteoporosis Use now

Higher inherited signal for Osteoporosis; measured phenotype decides whether that signal is showing up now.

Linked to: Match training levers to injury context
LowHigh
90Percentile
Migraine Use now

Headache-pattern context. Genetics is useful only when it sharpens a diary of attacks, aura, sleep, caffeine, alcohol, hormones, stress, training load, and medication use.

LowHigh
85Percentile
Step 4 of 6
For your doctor's visit, tests worth considering. A short, doctor-friendly summary of checks, context, and boundaries to discuss or save. Many common blood tests can also be ordered yourself online, but results still need real-life context.

Use this for doctor notes, routine blood-test follow-ups, and care conversations. It is not a diagnosis, urgent-care request, or medication instruction.

6 rows
Area Priority What to check Why now When it matters
Use low-regret metabolic levers first Medium Use measured lipids, glucose/HbA1c, waist/body-composition trend, blood pressure, sleep, alcohol, and activity baseline to choose the first lever.
  • Triglycerides 77th percentile
  • Type 2 diabetes >90%
  • HbA1c >90%
Borderline or high measured markers make the levers higher priority; normal markers let this stay as prevention maintenance.
Measure the lipid particle layer High ApoB-inclusive lipids: ApoB, LDL-C, non-HDL-C, triglycerides, and one measured Lp(a).
  • LDL cholesterol >90%
  • ApoB 78th percentile
  • Triglycerides 77th percentile
High ApoB, LDL-C, non-HDL-C, triglycerides, or Lp(a) should guide prevention intensity with your GP; normal results keep the DNA signal in context.
Confirm the glucose and HbA1c pattern High HbA1c plus fasting glucose; interpret discordance with iron, B12, red-cell indices, recent illness, training load, sleep, and medication context.
  • Type 2 diabetes >90%
  • HbA1c >90%
Borderline or high measured values move this into prevention planning; discordant values should be interpreted before drawing conclusions.
Let symptoms choose the gut-testing route High Track stool pattern, urgency, blood or mucus, nocturnal symptoms, pain, reflux, food timing, NSAID/PPI/antibiotic exposure, and family history for two weeks.
  • Irritable bowel syndrome >90%
  • IBD 85th percentile
  • Ulcerative colitis >90%
Blood, weight loss, nocturnal symptoms, anaemia, strong family history, or severe/progressive symptoms should move this from tracking to GP/GI review.
Match training levers to injury context Medium Current activity baseline, pain, injury history, recovery, sleep, resting HR/HRV, strength work, and any chest pain, fainting, or severe breathlessness.
  • Cardiorespiratory fitness / VO2max 18th percentile
  • Appendicular lean mass 81st percentile
  • Bone density 72nd percentile
  • Osteoporosis 90th percentile
Red-flag exercise symptoms or significant injury pause self-experimentation; good recovery supports gradual strength or aerobic progression.
PGx medication fileVariants affecting response to drugs Conditional See the medication notes panel below for matching medicine triggers and when to use them.
  • 9 medication-response contexts present
  • activate only at point of prescription.
Keep as a record-for-later note; do not change medicines from this report alone.
Why this may be worth bringing Key themes to discuss

Three themes stand out. First, measure the lipid particle layer. Second, confirm the glucose and HbA1c pattern. Third, gut genetics should be interpreted through symptoms and family history.

Suggested checks to consider Checks to consider

Discuss or book checks only if symptoms, abnormal previous blood tests, strong family history, medication questions or persistent fatigue make them relevant: lipid/glucose markers, liver markers/exposures, iron/B12/folate/thyroid context, blood pressure, waist/body-composition trend, and symptom logs where relevant.

Patient context needed Context that helps

Family history, current medicines and supplements, symptoms, alcohol pattern, diet, sleep, training load, and previous adverse drug reactions provide essential context.

Medication context Medicine considerations

9 prescribing contexts are present; use them only when a matching medicine is being chosen or reviewed.

Simple script

I have a DNA report that is not diagnostic. It suggests a few areas to check against real-world context. Could we review whether any routine blood tests or symptom history are relevant?

Medication notes

Keep these for prescribing moments.

These are record-for-later pharmacogenomic and exposure-response notes. They matter when a matching medicine is being started, stopped, switched, dose-adjusted, or reviewed for side effects.

Gene or marker Relevant medicines When to use it Boundary
Voriconazole metabolism (CYP2C19) Voriconazole Use only if voriconazole is ever being considered or monitored. Specialist prescribing context; clinical PGx confirmation may be needed before dosing.
PPI metabolism context (CYP2C19) Omeprazole, lansoprazole, pantoprazole, and related PPIs Use if a PPI is being chosen, dose-adjusted, used long term, or not working as expected. Prescribing context only; symptoms, indication, dose, and clinician advice decide use.
SSRI response/tolerability context (CYP2D6/CYP2C19/CYP2B6) Selected SSRIs and serotonin-reuptake antidepressants Use when an antidepressant is being selected, switched, dose-adjusted, or side effects are being reviewed. Do not start, stop, switch, or dose-adjust antidepressants without the prescribing clinician.
Clopidogrel activation (CYP2C19) Clopidogrel and antiplatelet decisions Use only if clopidogrel is being started, reviewed, or discussed after a cardiovascular event or procedure. Prescriber/pharmacist decision; do not change antiplatelet treatment from this report.
Tricyclic antidepressant context (CYP2D6/CYP2C19) Amitriptyline, nortriptyline, and related TCAs Use if a TCA is being considered for mood, pain, migraine, sleep, or another indication. Prescriber-led dosing and safety review; this is not a self-adjustment signal.
Statin muscle-symptom context (SLCO1B1/ABCG2/CYP2C9) Statins, especially if muscle symptoms or dose choice become relevant Use if a statin is being chosen, changed, or reviewed after muscle symptoms. Measured lipids, prevention risk, symptoms, CK if relevant, and clinician judgement decide treatment.
Metformin response context (IGF2R/SLC22A1) Metformin Use if metformin is being considered, response is unexpectedly poor, or tolerability is being reviewed. HbA1c/glucose pattern, kidney function, B12 context, dose, side effects, and clinician judgement decide action.

Do not start, stop, switch, or dose-adjust medication from this report without the prescribing clinician or pharmacist.

Optional
Why you are seeing only these findings. A plain-English look at how weak, noisy, or low-use signals are filtered out of your complete report.

This is the methods receipt. It explains how the report was assembled, not a task list.

5 layers

We screened many possible signals, but most do not become action items. A finding only moves forward when it has a plausible link to a real-world check, a safe everyday lever, a medication note, or a clinician conversation.

18K+genetic traits screened and prioritised
119M+variant records standardised in early build waves
66,438report-reference records connected to traits
What we checked

PRS percentiles, detected and not-detected marker calls, PGx contexts, HLA contexts where callable, evidence links, actionability, redundancy, and safety boundaries.

What we did not check

This is not diagnostic testing, whole-genome clinical variant interpretation, current lab testing, symptom assessment, medication review, or a substitute for formal screening pathways.

How to use it

Use the report as a prioritisation map. Measured results, symptoms, family history, medication context, and clinician judgement decide what changes now.

Prioritisation

We choose what is worth showing.

Traits and variants are ranked by actionability, inherited signal, value beyond ordinary biomarkers, validation, ancestry portability, redundancy, and safety. That keeps the report focused on useful context rather than every possible genetic association.

Genetic modelling

We use research-grade mapping, not simple SNP lookup.

Your DNA is harmonised to a modern genome build, imputed against high-coverage reference data, and mapped with LD-aware polygenic scoring approaches that account for the way nearby variants travel together.

Mechanisms

We go from risk scores to biological paths.

We look for the biological and practical routes that make a score usable: relevant biomarkers, symptoms, family-history questions, clinician conversations, and everyday levers.

Evidence layer

We link findings to checks, actions, and boundaries.

The current build uses 29,169 recommendation mappings, 10,062 mechanism concepts, and 66,438 report-reference records to connect traits to biomarkers, clinician discussion points, safety notes, and low-harm next steps.

Our research
pipeline
DNA fileYour raw DNA data securely processed
Imputation QCRigorous quality control and confidence tiers
PRS scoringLD-aware polygenic scores calibrated to population data
Evidence mappingLinking to literature, biomarkers, actions, and safety context
Report guidancePrioritised insights and actionable next steps

These methods support interpretation and prioritisation. They do not diagnose conditions or replace medical care.

Step 5 of 6
Overall, this is mostly good news. Use this map only if you want the detailed score view. Most rows do not need action from DNA alone.

This signal map groups findings by health area so you can browse by concern without treating every row as a task.

Mostly reassuring 55 map rows
Category signal scores run from 10-90. 50 is typical. Higher numbers mean more inherited signal to check, not a diagnosis.
10 lower 50 typical 90 check

Scores balance signals from component traits based on health relevance, DNA-score strength, evidence confidence, your percentile, age relevance, how common or serious the trait is, and overlap with related traits.

Lower inherited signal

Sleep & circadian rhythmLow inherited signal 20

3 contributing findings. Open any finding below to jump to its full result.

Lipoprotein(a) & clottingLow inherited signal 24

4 contributing findings. Open any finding below to jump to its full result.

Pancreas & ulcer contextLow inherited signal 24

3 contributing findings. Open any finding below to jump to its full result.

Cognition & memoryMildly lower signal 29

2 contributing findings. Open any finding below to jump to its full result.

Sleep chemistry contextMildly lower signal 39

10 contributing findings. Open any finding below to jump to its full result.

Protein & metabolic markersMildly lower signal 39

2 contributing findings. Open any finding below to jump to its full result.

Typical or steady

Dental & mouth healthTypical range 49

2 contributing findings. Open any finding below to jump to its full result.

Liver enzymesTypical range 49

5 contributing findings. Open any finding below to jump to its full result.

Cancer screening contextTypical range 48

9 contributing findings. Open any finding below to jump to its full result.

Nutrients & methylationTypical range 52

9 contributing findings. Open any finding below to jump to its full result.

Weight & body fatTypical range 46

2 contributing findings. Open any finding below to jump to its full result.

Heart & blood vesselsTypical range 55

8 contributing findings. Open any finding below to jump to its full result.

Fatty acids & lipid nutrientsTypical range 55

5 contributing findings. Open any finding below to jump to its full result.

Heart rhythmTypical range 56

3 contributing findings. Open any finding below to jump to its full result.

Sleep breathing & movementTypical range 44

4 contributing findings. Open any finding below to jump to its full result.

Muscle strength & body compositionTypical range 43

3 contributing findings. Open any finding below to jump to its full result.

Blood pressureTypical range 42

3 contributing findings. Open any finding below to jump to its full result.

Iron, B12 & blood countTypical range 42

15 contributing findings. Open any finding below to jump to its full result.

Sex hormonesTypical range 58

2 contributing findings. Open any finding below to jump to its full result.

Uric acid & goutTypical range 60

2 contributing findings. Open any finding below to jump to its full result.

Immunity & infectionsTypical range 60

3 contributing findings. Open any finding below to jump to its full result.

Skin conditionsTypical range 63

3 contributing findings. Open any finding below to jump to its full result.

Worth checking

Blood sugar controlHigher signal to understand 87

4 contributing findings. Open any finding below to jump to its full result.

Allergies & atopyHigher signal to understand 82

3 contributing findings. Open any finding below to jump to its full result.

Gut healthUseful check to consider 79

6 contributing findings. Open any finding below to jump to its full result.

Liver healthUseful check to consider 79

6 contributing findings. Open any finding below to jump to its full result.

Blood lipidsUseful check to consider 75

6 contributing findings. Open any finding below to jump to its full result.

Gut inflammationUseful check to consider 75

3 contributing findings. Open any finding below to jump to its full result.

Bone healthUseful check to consider 75

2 contributing findings. Open any finding below to jump to its full result.

Inflammation & autoimmuneUseful check to consider 73

5 contributing findings. Open any finding below to jump to its full result.

Eye healthUseful check to consider 73

2 contributing findings. Open any finding below to jump to its full result.

Kidney healthUseful check to consider 71

4 contributing findings. Open any finding below to jump to its full result.

Gallbladder, bile & fat digestionUseful check to consider 70

7 contributing findings. Open any finding below to jump to its full result.

i

Weighted by health relevance, genetic predictiveness, evidence quality, result confidence, age relevance, background frequency, redundancy, and distance from the reference average. Lower signal is not immunity. Higher signal is not diagnosis.

Step 6 of 6
Explore all your traits. Use these filters to move from health areas into the full individual trait library. Most rows need no action from DNA alone.
14 areas
Choose an area below to filter the optional audit library
14 areas 245 signals checked 5 starting routes
14 areas · 245 signals checked
Optional audit library Optional audit library. This is here so you can audit what was checked. It is not a longer to-do list.
245 signals
Confidence guide

PRS confidence Comparative percentile; useful for prioritising checks, not diagnosis.

Marker confidence Context layer; confirm clinically if action would change.

PGx confidence Prescribing note; use when a matching medicine is chosen or reviewed.

Action evidence Support for checks or low-harm levers, not treatment instructions.

View
39 priority rows shown · sorted by practical priority
Use now Check if relevant Background
Data-quality receipt Complete report · GRCh38 · issued 2026-06-09

Small provenance check for what went into this report.

Input gateUpload gate: accepted for phase 1; provider unknown; phase 1 supported.
Rendered data245 signals: 176 polygenic score rows and 69 marker/PGx/HLA context rows
Score readinessPRS readiness passed; 0 missing and 0 partial score runs recorded
Context layers103 callable marker rsIDs; 22 callable PGx contexts; 10 usable HLA allele calls
BoundaryThis is not diagnostic testing, current lab testing, rare-variant interpretation, or a substitute for formal screening or clinical review.